Embedding spatial bioanalysis into your discovery and development strategy will help you save money and time in the long run.
Our proprietary drug imaging workflows will enable you to study the distribution of drugs and biomarkers simultaneously
at the site of action.
Spatial bioanalysis will allow you to:
- Gain access to unique data for strategic decision making and lead optimization
- Understand localization, quantification, and distribution of drugs at the site of action
- Study the whole-body distribution of your drug and related metabolites in animal models without any labeling
- Select the right dose, mode of administration and/or formulation to expose your organ or target of interest
- Identify the molecular component of lesions observed in toxicity studies
- Simultaneously localize and quantify of thousands of markers with your drug in the tissue microe
Aliri’s proprietary drug imaging workflows will enable you to study the distribution of drugs and biomarkers simultaneously at the site of action.
This enables us to:
500+
Drug Development Studies using Mass Spectrometry Imaging
Our team is the leader in spatial bioanalysis with innovative technologies and proprietary software and methods. Both small and large pharma companies have been using our imaging technologies for more than a decade to detect elements, small drugs and markers directly on tissue sections.
Learn more about the equipment we use.
| Category | Matrix assisted laser desorption ionization technique (MALDI) imaging | Laser ablation inductively coupled plasma (LA-ICP) imaging | Imaging Mass Cytometry Hyperion |
|---|---|---|---|
| Overview | Detect intact molecules amino acids, metabolites, small drugs from frozen of FFPE tissues | Detects endogenous elements from tissue section from frozen of FFPE tissues. | Detects protein therapeutics using metal tagged antibodies from any type of tissues (Frozen of FFPE) |
| Throughput Samples / Day | Up to 50 | Up to 50 | Up to 50 |
| Resolution | 10μm | 10μm | SubCellular |
| Molecule Type | Small molecules, peptides, lipids, metabolites | Various elements such as gadolinium, platinum, lithium, sodium, potassium, magnesium, calcium, iron, cobalt, nickel, copper, zinc, silver | Biologics such as ADC, Ab fragments, bi-specific antibody, monoclonal antibody |
| Mass Accuracy | <1 ppm | Unit mass resoultion | Unit mass resolution |
| Plexing | 1000 | 10 | 40 |
| Sample Prep | Cryostat, Microtome, Histological AutoStainer | Cryostat, Microtome, Histological AutoStainer, Ventana Discovery Ultra | Cryostat, Microtome, Histological AutoStainer, Ventana Discovery Ultra |
| Quantification | Absolute quantification | Absolute quantification | Absolute quantification |
Is this molecule getting to the target cells?
How quickly is it getting to the target cell in tissue?
What is the mechanism of action of the targeted cells and its microenvironment?
Is my drug or metabolites the cause of the lesions observed during the toxicity studies?
Is the drug reaching the targeted cell activate the right pathway?
These techniques are a strong combination due to the ability to multiplex large quantities of targets, molecules, single cell resolution, and quantification.
Leveraging imaging early in your discovery process will help you with the evaluation and selection of your drug candidate by helping to answer your questions.