Gain access to unique data for analysis and decision making
Spatial bioanalysis and biology are solutions to help generate unique data that will help optimize strategic decisions and understand drug exposure at the site of action and the impact to the microenvironment. Adopting spatial bioanalysis and biology into your strategy early on, can help you save money and time in the long run.
Our spatial services provide deeper information about the efficacy of your drug or the relevance of biomarkers.
Aliri offers unique spatial services to study the distribution and concentration of drugs and/or biomarkers simultaneously in plasma, tissues, and cells. We can measure the impact of drugs early in vivo stage to support lead selection and validate mechanism of action (MOA). This is critical for translational research and early clinical stage to validate the drug bioavailability, penetration, and on target accumulation. Our additional solutions include, PD evaluation, phenotyping, pathway evaluation, and patient stratification.
Our proprietary imaging workflows will help you:
Understand localization, quantification, and distribution of drugs at the site of action
Measure the impact of drugs on cells and their efficacy at the cellular level
Decipher the complexity of the tissue microenvironment (TME) with quantification of the cell organization through transcriptomic, metabolomic or proteomic changes in disease models and human samples
Quantify components of a sample or to analyze their structure for increased specificity and sensitivity
Simultaneously localize and quantify of thousands of compounds
Services include:
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- Drug biodistribution and in situ metabolism
- Pharmacokinetics
- Target identification and disease characterization
- Pharmacodynamic
- Safety Evaluation
- Clinical pharmacology and drug exposure
- Digital Pathology
Spatial Platforms
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- Mass spectrometry imaging
- GeoMX spatially resolved gene and protein expression
- Laser microdissection
- Multimaging software solutions and image analysis
- Imaging mass cytometry services – High Multiplex IHC
- Histophathology and immunohistochemistry