LC-MS/MS is an advanced analytical technique that combines liquid chromatography (LC) with tandem mass spectrometry (MS/MS) to analyze complex mixtures of molecules. Because this method is highly sensitive and capable of quantifying molecules in complex samples, it is often used for protein/peptide analysis.
LC-MS/MS can optimize dwell times to improve sensitivity. During method development it’s important to monitor multiple charge states to determine which will afford better selectivity and sensitivity. Also consider different ion pairing reagents to drive the charge envelope into the mass range of the instrument.
Our tenured team of scientists have extensive experience applying LC-MS/MS to:
- Small molecules
- RNA therapeutics
- Peptides
- Proteins
- Lipid Nanoparticles
