In Situ PK-PD

Understanding the pharmacokinetics (PK) and pharmacodynamics (PD) of compounds within their native tissue environments is essential in drug development. Our advanced in situ PK-PD analysis leverages cutting-edge mass spectrometry imaging and spatial omics technologies to provide unparalleled insights into drug distribution, metabolism, and action at the cellular level. By visualizing the spatial distribution of drugs and their metabolites, alongside molecular changes in tissues, we enable more precise and effective drug development strategies. This holistic approach not only accelerates the drug discovery process but also enhances the accuracy of therapeutic targeting, ultimately leading to better patient outcomes.

Aliri performs in situ PK-PD using Quantitative Mass Spectrometry Imaging to deliver a complete investigation of the drug in specific organs at the histological level.  This unique approach allows us to evaluate the in vivo drug impact to the cells and compare animal models to human biopsies.

Our experience covers multiple therapeutic areas including CNS, oncology, immunology, metabolic diseases, dermatology, and more.