Quantitative MALDI Mass Spectrometry Imaging (QSMI) can be used to determine drug distribution in first-in-human studies
At WRIB 2023, Shane Karnik, Senior Laboratory Director at Aliri, presented a poster about utilizing QSMI to determine Bimiralizib distribution in human skin biopsies.
Recent clinical trial results validate Bimiralizib distribution in human skin and showcase:
- Robustness of MALDI MSI method
- Approach not limited to dermatology; already applied in oncology
- Absolute quantification allowed to determine if the compound reached the site of action
- Method allows to characterize small compound PK in clinical trial
- Method allows the characterization of the target engagement
Download our poster about utilizing QSMI to determine drug distribution.