Laser Capture Microdissection (LCM)

Tissue Heterogeneity is a common parameter to consider while measuring pharmacokinetics and pharmacodynamics results. When molecular imaging can’t provide enough information with sufficient sensitivity, Laser Capture Microdissection (LCM) coupled with Liquid Chromatography Mass Spectrometry (LC-MS) is a great alternative to measure molecular content of cells.

We have integrated LCM into our histology and bioanalytical departments to quantify biomolecules at the cellular level and uncover detailed cellular information.

Laser Capture Microdissection enables our team to isolate regions of interest from histology sections and capture small tissue samples into vials for further analysis. This technique allows us to measure the concentration of both drugs and endogenous molecules simultaneously.

Speak with an expert

We offer innovative services, including laser microdissection, advanced mass spectrometry, and genomics platforms, to unravel tissue complexity and accurately measure activity. By preserving the micro-environment, we can selectively target specific cells or regions of interest within tissues and quantify drugs and biomarkers at the cellular level.

For omics studies, LCM enables us to select specific regions of interest, which we then analyze using mass spectrometry to quantify cellular changes. This approach allows us to simultaneously measure the concentration of drugs, biologics, small molecules, as well as proteins, metabolites, mRNA, and genes.