The non-human primate (NHP) provides the most clinically relevant model of human tuberculosis. The aim of this study was to determine the tissue pharmacokinetics of orally delivered isoniazid (H), rifampicin (R), pyrazinamide (Z) and ethambutol (E) combination therapy (HRZE) in the lung of cynomolgus macaques to prepare following studies in Mycobacterium tuberculosis-infected animals usinq QMSI.
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