The ability to understand tissue heterogeneity is critical to answering key biological questions that will enable you to advance your molecule to the next phase. Profiling molecular phenotypes while retaining spatial information of expression is not only suggesting new relationships among signaling molecules, but it is also deepening our understanding of disease mechanisms that are critical to find spatial signatures of biomarkers. Therefore, leveraging spatial biology is relevant to understand the effect of the investigated drug.

Aliri has developed routine analysis of innovative molecular profiling high-multiplex assays combined with image analysis and digital pathology workflow services. These services are backed by a team of industry experts, so that you can correlate histopathology to molecular content organization for many applications in oncology, CNS, or metabolic disorders.

How can Aliri help you characterize disease state?

  • Provide spatially differentiated profiling of tumor driver and immuno-oncology proteins
  • Discover biomarkers related to location and signaling of specific cells
  • Analyze pathways across tissue structures and complexity
  • Provide basis for identifying clinically relevant associations with drugs

Learn more about the equipment we use:

CategoryMatrix assisted laser desorption ionization technique (MALDI) imagingImaging Mass Cytometry HyperionRNAScopeGeoMx Nanostring
Ncounter
Immuno-fluorescenceLaser ablation
inductively coupled plasma (LA-ICP) imaging
OverviewDetect intact endogenous molecules amino acids, metabolites, small drugs from frozen of FFPE tissuesDetects protein and RNA using metal tagged antibodies from any type of tissues (Frozen of FFPE)Detect siRNA or mRNA at single cells resolution with a very high sensitivityCombined with NGS, or standalone, the GeoMx makes it possible to quantify the distribution of hundreds of proteins or RNA from tissue sectionDetects endogenous elements from tissue section from frozen of FFPE tissues
Resolution10μmSubCellularSubCellular10μmSubCellular10μm
Molecule TypeSmall molecules, peptides, lipids, metabolitesLarge panels of biomarkers available for oncology, immuno-oncology, inflammation and fibrosisRNA and oligonucleotidesProteins and oligonucleotidesVarious elements such as gadolinium, platinum, lithium, sodium, potassium, magnesium, calcium, iron, cobalt, nickel, copper, zinc, silver
Plexing+1000+40Up to 5Up to +1000Up to 5+10
Sample PrepCryostat, Microtome, Histological AutoStainerCryostat, Microtome, Histological AutoStainer, Ventana Discovery UltraCryostat, Microtome, Histological Autostainer, Ventana Discovery UltraCryostat, Microtome, Histological AutoStainer, Ventana Discovery UltraCryostat, Microtome, Histological AutoStainer, Ventana Discovery UltraCryostat, Microtome, Histological Autostainer, Ventana Discovery Ultra
QuantificationAbsolute quantificationAbsolute quantificationAbsolute quantificationRelative quantificationRelative quantificationAbsolute quantification
Digital PathologyCombined with our data scientist, we analyze all the data into our proprietary software, customized data analysis process or vendor software depending on the requestCombined with our data scientist, we analyze all the data into our proprietary software, customized data analysis process or vendor software depending on the requestCombined with our data scientist, we analyze all the data into our proprietary software, customized data analysis process or vendor software depending on the requestCombined with our data scientist, we analyze all the data into our proprietary software, customized data analysis process or vendor software depending on the requestCombined with our data scientist, we analyze all the data into our proprietary software, customized data analysis process or vendor software depending on the requestCombined with our data scientist, we analyze all the data into our proprietary software, customized data analysis process or vendor software depending on the request
1000+

Molecular Images Analyzed

100+

Publications focusing on metabolomics, lipidomics, transcriptomics, and proteomics

Work with us to access & analyze spatial molecular arrangements in tissues.

 

Our team has technical expertise in spatial-omics with 100+ publications and 2,500+ bioassays. The possibility to correlate distribution maps of multiple markers with histological and clinical features makes it an ideal tool to advance your molecule.

Ready to implement a spatial biology strategy?