Elucidating the Role of IL-18 in NSCLC Integrated Analysis through Imaging Mass Cytometry, Mass Cytometry, and Single-Cell Sequencing
Interleukin-18 (IL-18) plays a pivotal role in nonsmall cell lung cancer (NSCLC) progression, influencing both tumor growth and immune response dynamics. Recent insights into the heterogeneity and functional status of tumorinfiltrating T cells have underscored their critical impact on antitumor immunity and responses to immunotherapy, paralleling the observed complexity in IL-8 interactions within the tumor microenvironment. This study employs Imaging Mass Cytometry (IMC), Mass Cytometry (CyTOF), and Single-Cell RNA Sequencing (scRNA-seq) to map IL-18 expression, explore its impact on immune cell subsets, and identify its role in the tumor microenvironment
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