Drug discovery and bioanalysis solutions
Due to limited time, funds, and resources within discovery, it can be challenging to strike the right balance of speed, cost, and quality. Drug discovery quick turnarounds are imperative to keep your program on track.
Our specialized discovery team provides support for small molecules, peptides & proteins, and oligonucleotides. Our ability to provide technical expertise and quick turnaround will instill confidence and enable you to move onto the next phase in your program with ease.
Trusting us with your discovery project grants you access to:
- 48-hour data delivery
- Data in the format that meets your needs
- Identification for molecule advancement
- Access to expert scientists
- Flexibility to change or accelerate timelines
Download our comprehensive guide to learn how our quick turnarounds for lead optimization can expedite your process
from discovery to clinical.
Buy vs Build: Bioanalytical lab
Buying a bioanalytical lab vs. building one yourself – what do you need to consider?
With so many outsourcing/insourcing options across the drug development workflow, Pharma companies are faced with finding the right partner to fit all the needs of their unique molecule. Here are some criteria to consider:
- Time to Launch: timelines depend on the approach. A built-for-purpose project translates to long timelines due to all the parties involved. You need time to evaluate location, engineers, & architects. Return on investment and risk impact: both are dependent on the number of programs and the diversity of projects. To fully evaluate, you need to build utilization models to analyze and make predictions
- Staffing appropriately: the job market can be challenging to navigate, and it could prove to be challenging to find the right expertise and employees. Be prepared for this process to take time and be costly.
- Day to Day Logistics: there are a wide variety of permits & licenses needed for day-to-day operations. This regulatory environment can be complicated to navigate as you manage the applications, requirements and maintenance required.
If you are interested in learning more about permits & licenses specifically, check out our fact sheet: Guidelines to Importing & Exporting Biological Samples - And much more…
Explore our comprehensive guide that outlines the benefits & risks associated with buying or building a bioanalytical lab and see what choice is best for you.
Guidelines: Importing & Exporting Biological Samples
The United States government has a heavily regulated process for importing and exporting biological samples, and for good reason. These protocols are designed to prevent the transportation of exotic diseases and to inhibit the supply to illegal markets.
While understanding the reasons for the high regulation, it can still be extremely complicated to navigate the different governing bodies and acquire the correct applications or permits. Failure to follow the process also has dire consequences: samples can get held at customs, there may be fines involved, and your estimated drug development timeline just got much longer.
We know how frustrating delays in your development process are. Our comprehensive guide gives you the information you need to be confident that your samples will not be compromised, and your timeline will not be delayed. Download our comprehensive guide to learn how to properly import and export biological samples to avoid potential issues and stay on track.
BIOANALYSIS: Approaches and Techniques for Small vs. Large Molecules
Bioanalysis plays a crucial role in the evaluation of potential drug candidates and in understanding the drug’s pharmacokinetics and pharmacodynamic profile during early clinical trials. By documenting a drug’s behavior within the body, our specialists generate essential data that regulatory authorities rely on to determine whether the drug is safe for market release.
Before choosing a suitable testing technique, it’s important to understand three factors, type of molecule, unique properties of the drug, and its intended application. Regardless of the molecule size, it’s crucial to validate appropriate methods capable of measuring the drug’s concentration and bioactivity over time.
Download our infographic to learn more.
Importing and exporting biological samples: Dos and don’ts
To ensure that your drug program’s timeline stays on track, it is crucial to follow the strict guidelines for importing and exporting biological samples. Too often, there are several mistakes with execution that could have been avoided with proper planning, coordination, and communication. These errors not only lead to frustration but also can result in:
- Costly delays
- Project rework
- Logistic challenges
- Lost, delayed, or damaged samples
- Handling mishaps
Discover the 5 best practices and mistakes to avoid when navigating the import and export of biological samples.
Build a bioanalytical strategy that will ensure speed and agility
In order to build a robust bioanalytical strategy for your drug discovery program, it’s crucial to collaborate with a partner who possesses both industry expertise and a track record of operational success.
Aliri by the numbers:
- 48-hour turnarounds in discover
- 150 biological fluids & tissues
- 1 million samples analyzed
Our team of seasoned scientists, industry experts, program managers, and quality specialists can help you develop a successful bioanalytical strategy that will maximize the growth of your drug discovery investments. Work with us to gain access to a robust suite of mass spectrometry platforms, achieve quality data to quickly file your IND, NDA and CTA, and forecast potential roadblocks that may cause delays in your project’s timeline.
Download our factsheet to explore our offerings, platforms, compounds, regulations and more.
The Future of Small and Large Molecule Bioanalytics—Today
In bioanalysis, the future of small and large molecules offers exciting prospects for advancements in drug discovery, diagnostics, and therapeutics. With the increase of larger substances, emerging technologies, and new analytical approaches, drug developers are faced with both new opportunities to evaluate complex substances, and new challenges to address. Therefore, it’s important to learn which bioanalysis techniques are right for your drug.
In this white paper, you’ll learn about:
- Bioanalysis by molecular size
- Advancements in mass spectrometry
- Visualization and quantification of drug distribution
- The era of spatial imaging
- Novel technologies and adaptions
For more information about emerging technologies revolutionizing the field of bioanalysis, download our whitepaper today.
Common Approaches to Bioanalysis of Oligonucleotides
The significance of oligonucleotides (OGNTs) in drug development is increasing rapidly, as they offer promising and life-changing treatments that can improve patients’ lives. However, the promising and vast opportunities of OGNTs come with a unique set of challenges and nuances unlike other types of molecules.
Within bioanalysis, there are 5 main approaches for OGNTs to consider:
- LC/UV
- LC/MS/MS
- Hybridization LF/FD
- LC/HRMS
- Hybridization ELISA
Learn how to evaluate the pros and cons of each approach to decide what’s best for your OGNTs.
Non-proprietary Assays
There are many factors to consider when choosing a bioanalysis partner for your project. One of which should be finding a company with the scientific expertise and resources you need to move forward with speed, accuracy, and certainty. One of those resources being a large assortment of assays.
Aliri has over 1500 non-proprietary assays that allow us to measure a wide variety of compounds using our advanced technology. Our expertise will advance your molecule with speed and agility!
Our species matrices include:
- Human Plasma
- Human Serum
- Human Whole Blood
- Whole Blood
- Human Dried Blood Spot
- Human Urine
Most common Assays:
- Budesonide
- Bupropion, Hydroxybupropion
- Diclofenac
- Naloxone
- Naltrexone/ Naltrexol
- Pregabalin
- Riluzole
- Rosuvastatin
- Rosuvastatin/ Desmethyl Rosuvastatin/ Rosuvastatine Lactone
- Tenofovir
- Tiotropium
Download our latest comprehensive list of non-proprietary assays available for you.