Predictive bioanalytical strategies for the development of Antibody-Drug Conjugates (ADCs)
ADCs often fail because the drug gets to the right tissue, but misses its target. It’s not enough to just seek the concentration of your ADC in the tissue, you need to know its exact location to predict efficacy and move your development program forward with confidence. In this webinar, renowned scientists and industry thought leaders Troy Voelker and Corinne Ramos outline a holistic bioanalytical strategy for your ADC, incorporating traditional bioanalysis with spatial bioanalysis to reveal decision-making data about how your ADC engages with the complex microenvironment.
Join us to learn step by step how to de-risk your ADC program with guidance on assessing:
- Antibody payload concentration
- Conjugated antibody concentration
- Free payload concentration
- Spatial distribution
- Target engagement
- Toxicity