Quantifying and Mapping ATP Distribution Within Tissues to Inform Targeted Therapeutic Strategies in Drug Development
ATP levels, as indicators of cellular metabolic activity, offer critical insights into the viability and growth dynamics of tumor cells, presenting potential targets for therapeutic strategies. The aim of this study is to explore how ATP distribution and quantification across various mouse tumor models can optimize drug development approaches. For this purpose, we utilized Quantitative Mass Spectrometry Imaging (QMSI) to measure ATP levels in different mouse models, determining the most suitable model for targeted drug development.
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