Knowing when to use Quantitative Mass Spectrometry Imaging (QMSI) instead of Quantitative Whole-Body Autoradiography (QWBA) can make or break a timeline and budget for pharma and biotech companies.
Consider the following key advantages when selecting which technique is right for your drug development program:
QSMI Advantages:
- Label-free quantification of thousands of analytes
- Excellent differentiation among parent drugs, metabolites, and other substances
- Highly specific in quantification by location in tissue
QWBA Advantages:
- Highly precise quantification capabilities, even at low and high limits of detection
- Spatial resolution at the cellular level
- Gold standard technique for the late-stage regulatory distribution studies
Even though QWBA remains the gold standard technique during late stage for regulatory agencies, QMSI is frequently used in support of the autoradiography in certain circumstances.
Further evaluate the benefits and risks associated with each technology.