Exploring the Spatial Distribution of mRNA-Lipid Nanoparticles in Mouse Whole-Body and Isolated Organs Using MALDI MSI
To investigate the biodistribution and potential toxicity of lipid nanoparticles (LNP1 and LPN2), which are crucial carriers for mRNA-based treatments after administration to male and female mice, by analyzing their distribution in whole-body carcasses and specific organs using MALDI-MSI.
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Development of Quantitative MALDI Mass Spectrometry Imaging Methods for Studying Distribution of Antituberculosis Drugs at their Site of Action
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTb), remains a global health challenge, with treatment involving a year-long regimen of four drugs: Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. However, the emergence of drug resistance calls for the development of new therapeutic molecules. Due to the complex granulomatous lesions formed by MTb, plasma drug concentrations often do not reflect tissue drug levels, making it crucial to assess drug exposure at the site of action. To address this, we have developed Mass Spectrometry Imaging (MSI) methods to study the distribution of anti-TB drugs and their metabolites, including pyrazinoic acid, across both healthy and diseased tissues.
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