Small Molecules

Developing and validating rugged methods for optimizing small molecule drug development study execution is pivotal in the journey toward regulatory approvals. A methodic approach not only ensures consistency and reliability in data, but also empowers you to make informed decisions, enhancing the efficiency and success of your project.

Aliri has implemented a robust approach, including 7 crucial steps below, to help you navigate the complexities and uncertainties that come with advancing small molecules for drug development.

  1. MS Tuning
  2. HPLC Separation
  3. Sample Preparation
  4. Stability
  5. Matix Effects
  6. Moving from method development into method validation
  7. Moving from method validation into sample analysis

Large Molecules

Large molecule drugs require advanced bioanalytical support, and Aliri is proud to offer robust experience and solutions that leverage LC-MS/MS and HRMS (high-resolution mass spectrometry), including:

  • Vast biologic diversity spanning from small (1 kDA) therapeutic peptides to large (900 kDA IgM) proteins
  • A wide range of sample preparation methods — simple protein precipitation to complex affinity capture enrichment techniques
  • Development and validation of mass spectrometry assays using surrogate peptides produced by proteolytic digestion of proteins for quantification
  • Semi-quantitative analysis of intact proteins (>10 kDA) molecule projects
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