The Complexity of the Gastrointestinal Tract: A Multilayered Challenge for Drug and Biomarker Studies
The gastrointestinal (GI) tract is a highly specialized and dynamic system, playing a central role in digestion, absorption, immune response, and microbiome interaction. From the stomach to the small intestine (duodenum, jejunum, ileum) and the large intestine (colon, rectum), each segment presents unique physiological and structural characteristics that influence drug delivery and…
Small and Large Molecules
Small Molecules Developing and validating rugged methods for optimizing small molecule drug development study execution is pivotal in the journey toward regulatory approvals. A methodic approach not only ensures consistency and reliability in data, but also empowers you to make informed decisions, enhancing the efficiency and success of your project.
Aliri has implemented a robust…
Spatial distribution of B cells and lymphocyte clusters for the treatment of non-small cell lung cancer
Explore the spatial organization of tertiary lymphoid structures (TLS) in non-small cell lung cancer (NSCLC) and its impact on ant-PD-1 treatment response in our poster presentation. Using high-plex imaging mass cytometry staining, we investigated the relationship between TLS spatial organization, the tumor microenvironment, and patient response to therapy. We leveraged deep…
Optimizing small molecule drug development strategies: A step by step approach to a rugged method
Creating a rugged method for the development of small molecule drugs is crucial in the quest for successful therapies. A systematic approach not only guarantees data consistency and reliability but also empowers you to make well-informed decisions, ultimately boosting project efficiency and success.
To help you navigate the complexities and uncertainties that come with advancing…
A Comprehensive Guide to Optimizing Your Small Molecule Drug Development Strategy
Given that small molecules make up more than 50% of the drug development pipeline, adopting a proactive non-clinical to clinical strategy is crucial for accelerating your program.
A holistic bioanalysis strategy that incorporates spatial analysis allows researchers to produce quality data, identify drug targets, evaluate efficacy, and optimize delivery. Join industry experts Troy Voelker…
A Comprehensive Guide to Optimizing Your Small Molecule Drug Development Strategy
CONTACT US to learn more about Aliri's extensive experience with this technology.
Spatially-resolved tumor gene expression analysis
As cancer advances, tumor cells come into contact with new cell types within the microenvironment, but it is still unclear how the tumor cells adapt to new environments. Spatial transcriptomics is a powerful approach to uncover mechanisms that allow tumors to invade the microenvironment and help discover biomarkers for potential therapeutic targets.
In this application note,…
An automated complementary method for spatially resolved quantitative analysis of drugs and biomarkers
Having an initial understanding of drug distribution, quantification and target engagement within disease-relevant histological structures is critical in choosing more effective drug candidates. MALDI MSI unveils the quantitative distribution of label-free drugs, or biomarkers, providing valuable data that complements information obtained through traditional approaches. Our…
A guide to the advantages and disadvantages of sample preparation for small molecules
Accurate and reliable results in the drug discovery process rely heavily on the pivotal role of sample preparation. By adopting optimized sample preparation techniques, you can significantly improve the quality of your data.
Sample preparation for small molecules involves three primary modes:
Protein precipitation
Supported liquid exchange / liquid/liquid extraction
Solid phase…